研發成果智慧財產權及其應用績效
一、專利:檢測單核細胞增多性李斯特菌之引子及其方法
二、技術移轉:
台灣綠茶優良品系之ITS
分子基原鑑定與活性成分之
HPLC 指紋圖譜關鍵技術之建立
其他協助產業技術發展之具體績效
  1. 主持『紅麴中藥新藥』的研發:成功研發『降血酯』健康食品上市,該專案並獲得經濟『海外歸國學人』補助(FY90~91)。
  2. 先期參與並負責執行藥技中心技術移轉之『抗潰瘍中草藥』新藥研發(FY90~91):該案成果取得美國地區抗潰瘍藥品的第一期臨床試驗許可。目前已有蔘能、活衛仙及人蔘守衛適等食品產品上市。
  3. 執行『抗憂鬱中草藥』研發:先期參與並負責執行藥技中心技術移轉之『抗憂鬱中草藥』新藥研發(FY91~92),建立『中草藥活性成分萃取技術平台』技術並取得代表該技術的PharmTECPrint產品商標使用授權。本技術將可應用於其它中草藥活性成份之濃縮及各種標準品之分離純化。
  4. 由益生菌生產含有特殊控制血糖量的活性成分(FY90-92):已完成製程開發並單離出控制血糖的活性成分。體外及動物試驗已經證實產品的控制血糖效果。
近三年內執行及申請中之研究計畫
一、科技部:
計畫一:台灣土肉桂葉精油及其主要成分於高尿酸血症相關之急、慢性病症之抗發炎作用及相關機制之探討(104-2320-B-040-022-MY3)
計畫二:台灣土肉桂葉精油及其主要成分對於內毒素誘發之小腸黏膜損傷之保護作用及模式辨識受體TLR4與NALP3在其中扮演之角色(101-2313-B-040-008-MY3)

二、其他機構補助申請
計畫一:開發移動式臭氧超微細胞泡沫機模組
計畫二:開發臭氧水離子清洗系統模組於蔬果延鮮 及去除農藥殘留應用
計畫三:五年一貫茶產業人才培育
計畫四:106年度高風險產品偵測及監控預測研究
計畫五:「食尚管理、農法自然」 - 公益大葉食安小草養成計畫
授課領域/技術專長
食品科學、保健食品、食品檢驗與分析、農業生化與分子生物技術
期刊論文-著作目錄
  1. Shih-Chieh Lee*, Chia-Hsiang Wang, Cheng-En Yen, Chieh Chang. (2016, Jul).DNA barcode and identification of the varieties and provenances of Taiwan's domestic and imported made teas using ribosomal internal transcribed spacer 2 sequences.. Journal of Food and Drug Analysis, DOI:http://dx.doi.org/10.1016/j.jfda.2016.06.008. 本人為第一作者、通訊作者.
  2. Shih-Chieh Lee, Chun-Hao Chen, Chih-Wen Yu, Hsiao Ling Chen, Wei-Tung Huang, Yun-Shiang Chang, Shu-Hsien Hung, and Tai-Lin Lee.* (2016, Apr).Inhibitory effect of Cinnamomum osmophloeum Kanehira ethanol extracts on melanin synthesis via repression of tyrosinase expression.. Journal of Bioscience and Bioengineering, 122,263-269. 本人為第一作者.
  3. Chun-Chieh Wang, Chi-Tang Ho, Shih-Chieh Lee*, Tzong-Der Way.* (2016,Mar). Isolation of eugenyl beta-primeveroside from Camellia sasanqua and its anticancer activity in PC3 prostate cancer cells.. Journal of Food and Drug Analysis, 24, 105-111. 本人為通訊作者.
  4. Feng-Ming Yeh, Der-Chin Chen*, Jui-To Wang, Shih-Chieh Lee, Siak Lim Lee.(2016, Mar). New inspection method of visual refractive error using brainwave patterns.. Procedia Engineering (EI), 140, 85 – 94.
  5. Shih-Chieh Lee, Jie-Sheng Hsu, Chien-Chun Li, Ke-Ming Chen, Cheng-Tzu Liu(2015, Feb). Protective Effect of Leaf Essential Oil from Cinnamomum osmophloeum Kanehira on Endotoxin-Induced Intestinal Injury in Mice Associated with Suppressed Local Expression of Molecules in the Signaling Pathways of TLR4 and NLRP3.. PLoS One, 10(3): e0120700.. 本人為第一作者.
  6. Shiang-Suo Huang, Yi-Hui Yan, Chien-Hui Ko, Ke-Ming Chen, Shih-Chieh Lee,Cheng-Tzu Liu (2014, Jul). A Comparison of Food-grade Folium mori (桑葉Sāng Yè) Extract and 1-Deoxynojirimycin for Glycemic Control and Renal Function in Streptozotocin-induced Diabetic Rats. Journal of Traditional and Complementary Medicine, 4(3):162?170. MOST 94-2320-B-040-035. This work was supported by a grant from the NSC foundation of the National Science Council (94-2320-B-040-035-). We acknowledge Chin Ang Pharmaceutical Co.,Ltd (Chiayi, Taiwan)for providing the F. mori preparation..
  7. Ying-I Chen, Yu-Wen Cheng, Chung-Yuh Tzeng, Yu-Chen Lee, Yaw-Nan Chang, Shih-Chieh Lee, Chin-Chun Tsai,Jaw-Chyun Chen, Jason Tze-Cheng Tzen and Shih-Liang Chang (2014, Jan). Peroxisome roliferator-activated receptor activating hypoglycemic effect of Gardenia jasminoides Ellis aqueous extractand improvement of insulin sensitivity in steroid induced insulin resistant rats.BMC Complementary and Alternative Medicine, 14:30. MOST 101-2320-B-212-001-MY2. We thank the National Science Council of Taiwan (NSC101-2320-B-212-001-MY2, NSC101-2632-E-212-001-MY3) and Taichung Veterans General Hospital and Da-Yeh University joint project (TCVGH-DYU-1018303) for funding this research. We also thank Miss Xin-Ping Ku for her assistance..
  8. Shih-Chieh Lee, Wen-Xin Xu, Li-Yun Lin,Jia-Jung Yang, and Cheng-Tzu Liu (2013, Apr). Chemical omposition and Hypoglycemic and Pancreas-Protective Effect of Leaf Essential Oil from Indigenous Cinnamon Cinnamomum osmophloeum Kanehira). J. Agric. Food Chem., 61, 4905-4913. 本人為第一作者. (SCI).
  9. Yu-Cheng Chiang, Wan-Wen Liao, Chia-Wei Lin, Chien-Ku Lin, and Hau-Yang Tsen,Shih-Chieh Lee,and Hsien-Huang Wang. (2013, Jan). Combination of an Immunomagnetic Separation Method and a Chromogenic Oligonucleotide Array for the Detection of Beer-Spoilage Lactic Acid Bacteria.. J. Am. Soc. Brew. Chem., 71(1):57-62. (SCI).
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